Targeting IL-6 in the treatment of inflammatory and autoimmune diseases
Background: IL-6, a glycoprotein composed of 212 amino acids in human, has a wide range
of biological activity, including regulation of immune response, support of hematopoiesis …
of biological activity, including regulation of immune response, support of hematopoiesis …
Targeting interleukin-6 in rheumatoid arthritis
MY Md Yusof, P Emery - Drugs, 2013 - Springer
Abstract Interleukin (IL)-6 is a potent pro-inflammatory agent that plays a crucial role in the
pathogenesis of systemic inflammatory disease. Targeting this pathway in rheumatoid …
pathogenesis of systemic inflammatory disease. Targeting this pathway in rheumatoid …
Immunotherapeutic implication of IL-6 blockade
T Tanaka, T Kishimoto - Immunotherapy, 2012 - Taylor & Francis
IL-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6 contributes to host
defense against acute environmental stress, continuous IL-6 production plays a significant …
defense against acute environmental stress, continuous IL-6 production plays a significant …
Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: current perspectives and future directions
A Ogata, T Tanaka - International journal of rheumatology, 2012 - Wiley Online Library
Interleukin (IL)‐6 is a cytokine featuring redundancy and pleiotropic activity. While IL‐6,
when transiently produced, contributes to host defense against acute environmental stress …
when transiently produced, contributes to host defense against acute environmental stress …
Inhibiting interleukin-6 in rheumatoid arthritis
E Choy - Current rheumatology reports, 2008 - Springer
Abstract Interleukin (IL)-6 is the most abundant proinflammatory cytokine in the circulation
and synovial joints of patients with active rheumatoid arthritis. It has pivotal roles in the …
and synovial joints of patients with active rheumatoid arthritis. It has pivotal roles in the …
Tocilizumab: an updated review of its use in the treatment of rheumatoid arthritis and its application for other immune-mediated diseases
T Tanaka, A Ogata, M Narazaki - Clinical Medicine Insights …, 2013 - journals.sagepub.com
Interleukin-6 (IL-6), produced by a variety of cells, is a typical cytokine featuring redundancy
and pleiotropic activity. IL-6 is promptly and transiently synthesized in response to infections …
and pleiotropic activity. IL-6 is promptly and transiently synthesized in response to infections …
The role and therapeutic targeting of IL-6 in rheumatoid arthritis
M Narazaki, T Tanaka, T Kishimoto - Expert review of clinical …, 2017 - Taylor & Francis
Introduction: Rheumatoid arthritis (RA) is an autoimmune chronic disease with joint and
systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA …
systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA …
Inhibition of IL-6 for the treatment of inflammatory diseases
N Nishimoto, T Kishimoto - Current opinion in pharmacology, 2004 - Elsevier
Interleukin-6 (IL-6) is a pleiotropic cytokine with various biological activities. Deregulated
overproduction of IL-6 has been found to play pathological roles in chronic inflammatory …
overproduction of IL-6 has been found to play pathological roles in chronic inflammatory …
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis
Y Ohsugi, T Kishimoto - Expert opinion on biological therapy, 2008 - Taylor & Francis
Background: IL-6 is a pro-inflammatory cytokine with multiple roles in the pathogenesis of
rheumatoid arthritis (RA). Targeting IL-6 with the humanized anti IL-6 receptor antibody …
rheumatoid arthritis (RA). Targeting IL-6 with the humanized anti IL-6 receptor antibody …
Tocilizumab: blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders.
K Paul-Pletzer - Drugs of Today (Barcelona, Spain: 1998), 2006 - europepmc.org
Interleukin (IL)-6 contributes to a myriad of physiologic and pathophysiologic processes.
Among its many physiologic functions, IL-6 plays an active role in immunology, inflammatory …
Among its many physiologic functions, IL-6 plays an active role in immunology, inflammatory …