Cancer is a multi-factorial disease and variation in genetic susceptibility, due to inherited
differences in thecapacity to repair mismatches in the genome, is an important factor in the …

AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in
mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer …

Abstract Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their
relation with MTHFR status in gastric patients who were confirmed with pathological …

Introduction Gastric cancer (GC) is one of the leading causes of cancer-related death in Iran.
Genome stability is one of the main genetic issues in cancer biology which is governed via …

Background: Human mutL homolog 1 (hMLH1) is located on chromosome 3q21-23. As a
classic tumor suppressor gene, many researchers have studied the association between …

Gastric cancer (GC) is the fourth most prevalant cancer and the second leading cause of
cancer-related mortality worldwide. As in other cancers gastric carcinogenesis is …

AIM: To investigate CpG methylation and single nucleotide polymorphism (SNP) of a specific
promoter region of hMLH1 in primary gastric carcinoma. METHODS: Primary gastric …

Gastric cancer is one of the most common malignancies. DNA methylation is implicated in
DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation …

Aim: We carried out a case–control study in an Omani Arab population to investigate the
association between gastric cancer and peripheral blood leukocyte DNA methylation in …

We aimed to explore the association between aberrant DNA methylation of the O (6)-
methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) …