The global regulator H‐NS binds to two distinct classes of sites within the Tn10 transpososome to promote transposition
CM Ward, SJ Wardle, RK Singh… - Molecular …, 2007 - Wiley Online Library
The histone‐like nucleoid structuring protein (H‐NS) is a global transcriptional regulator that
influences stress response and virulence pathways in Gram‐negative bacteria. H‐NS also …
influences stress response and virulence pathways in Gram‐negative bacteria. H‐NS also …
The global regulator H-NS acts directly on the transpososome to promote Tn10 transposition
SJ Wardle, M O'Carroll, KM Derbyshire… - Genes & …, 2005 - genesdev.cshlp.org
The histone-like nucleoid structuring (H-NS) protein is a global transcriptional regulator that
is known to regulate stress response pathways and virulence genes in bacteria. It has also …
is known to regulate stress response pathways and virulence genes in bacteria. It has also …
The global bacterial regulator H-NS promotes transpososome formation and transposition in the Tn5 system
CR Whitfield, SJ Wardle, DB Haniford - Nucleic acids research, 2009 - academic.oup.com
The histone-like nucleoid structuring protein (H-NS) is an important regulator of stress
response and virulence genes in gram-negative bacteria. In addition to binding regulatory …
response and virulence genes in gram-negative bacteria. In addition to binding regulatory …
[HTML][HTML] Identification of basepairs within Tn5 termini that are critical sfor H-NS binding to the transpososome and regulation of Tn5 transposition
CR Whitfield, BH Shilton, DB Haniford - Mobile DNA, 2012 - Springer
Abstract Background The H-NS protein is a global regulator of gene expression in bacteria
and can also bind transposition complexes (transpososomes). In Tn5 transposition H-NS …
and can also bind transposition complexes (transpososomes). In Tn5 transposition H-NS …
H-NS binds with high affinity to the Tn10 transpososome and promotes transpososome stabilization
SJ Wardle, A Chan, DB Haniford - Nucleic acids research, 2009 - academic.oup.com
H-NS is a bacterial DNA-binding protein that regulates gene expression and DNA
transposition. In the case of Tn10, H-NS binds directly to the transposition machinery (ie the …
transposition. In the case of Tn10, H-NS binds directly to the transposition machinery (ie the …
Characterization of the Tn5 transposase and inhibitor proteins: a model for the inhibition of transposition
NB de la Cruz, MD Weinreich, TW Wiegand… - Journal of …, 1993 - Am Soc Microbiol
Tn5 is a composite transposon consisting of two IS50 sequences in inverted orientation with
respect to a unique, central region encoding several antibiotic resistances. The IS50R …
respect to a unique, central region encoding several antibiotic resistances. The IS50R …
The nucleoid binding protein H-NS acts as an anti-channeling factor to favor intermolecular Tn10 transposition and dissemination
RK Singh, J Liburd, SJ Wardle, DB Haniford - Journal of molecular biology, 2008 - Elsevier
Dissemination of the bacterial transposon Tn10 is limited by target site channeling, a
process wherein the transposon ends are forced to interact with and insert into a target site …
process wherein the transposon ends are forced to interact with and insert into a target site …
Transpososome dynamics and regulation in Tn10 transposition
DB Haniford - Critical reviews in biochemistry and molecular …, 2006 - Taylor & Francis
Tn10 is a bacterial transposon that transposes through a non-replicative mechanism. This
mode of DNA transposition is widely used in bacteria and is also used by “DNA-based” …
mode of DNA transposition is widely used in bacteria and is also used by “DNA-based” …
The effect of host‐encoded nucleoid proteins on transposition: H‐NS influences targeting of both IS903 and Tn10
B Swingle, M O'Carroll, D Haniford… - Molecular …, 2004 - Wiley Online Library
Nucleoid proteins are small, abundant, DNA‐binding proteins that profoundly affect the local
and global structure of the chromosome, and play a major role in gene regulation. Although …
and global structure of the chromosome, and play a major role in gene regulation. Although …
Tn5 transposase loops DNA in the absence of Tn5 transposon end sequences
Transposases mediate transposition first by binding specific DNA end sequences that define
a transposable element and then by organizing protein and DNA into a highly structured and …
a transposable element and then by organizing protein and DNA into a highly structured and …