Efficient and specific signaling by mitogen-activated protein kinases (MAPKs) is enhanced
by docking sites found on many MAPK substrates and regulators. Here we show that the …

Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small
eyes, and poorly pigmented eyes and skin. A search for MITF-associated proteins, using a …

The extracellular signal-regulated kinase (ERK) pathway is an essential component of
developmental signaling in metazoans. Previous models of pathway activation suggested …

Mitogen-activated protein (MAP) kinases control gene expression in response to
extracellular stimuli and exhibit exquisite specificity for their cognate regulators and …

The microphthalmia-associated transcription factor (MITF) is a master regulator of the
melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including …

Microphthalmia (mi) is a transcription factor that plays a major role in the regulation of growth
and function in mast cells and melanocytes. Association ofmi with other proteins is a critical …

The C-terminal region of mitogen-activated protein kinase kinase-1 and 2 (MKK1 and MKK2)
may function in regulating interactions with upstream kinases or the magnitude and duration …

ERK5 is a recently characterized MAPK, which is most similar to the well studied ERK1/2
subfamily but uses distinct mechanisms to elicit responses. To understand the specificity of …

purpose. To characterize the extracellular signal-regulated kinase (ERK) pathway in the lens
and to try to understand how this pathway contributes to lens function and cataractogenesis …

The microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine
zipper protein that plays major roles in the development and physiology of vertebrate …