Glycointeractome of Neisseria gonorrhoeae: identification of host glycans targeted by the gonococcus to facilitate adherence to cervical and urethral epithelial cells

EA Semchenko, AV Everest-Dass, FEC Jen… - MBio, 2019 - Am Soc Microbiol
Neisseria gonorrhoeae is a significant threat to global health for which a vaccine and novel
treatment options are urgently needed. Glycans expressed by human cells are commonly …

[HTML][HTML] Intimate relations: molecular and immunologic interactions between Neisseria gonorrhoeae and HIV-1

F Guvenc, R Kaul, SD Gray-Owen - Frontiers in microbiology, 2020 - frontiersin.org
While the global incidence of human immunodeficiency virus (HIV-1) remains well above
UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral …

[HTML][HTML] Inhibition of Wnt Signaling Pathways Impairs Chlamydia trachomatis Infection in Endometrial Epithelial Cells

J Kintner, CG Moore, JD Whittimore… - Frontiers in Cellular …, 2017 - frontiersin.org
Chlamydia trachomatis infections represent the predominant cause of bacterial sexually
transmitted infections. As an obligate intracellular bacterium, C. trachomatis is dependent on …

Preclinical testing of vaccines and therapeutics for gonorrhea in female mouse models of lower and upper reproductive tract infection

KL Connolly, M Pilligua-Lucas, C Gomez… - The Journal of …, 2021 - academic.oup.com
Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable
systems for studying N. gonorrhoeae adaptation to the female host and immune responses …

Role of the gonococcal neisserial heparin binding antigen in microcolony formation, and serum resistance and adherence to epithelial cells

EA Semchenko, TD Mubaiwa, CJ Day… - The Journal of …, 2020 - academic.oup.com
The sexually transmitted infection gonorrhoea is on the rise worldwide and an increased
understanding of the mechanisms of colonization and pathogenesis of Neisseria …

[HTML][HTML] Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production

BI Baarda, RA Zielke, A Le Van, AE Jerse… - Plos …, 2019 - journals.plos.org
The six-component maintenance of lipid asymmetry (Mla) system is responsible for
retrograde transport of phospholipids, ensuring the barrier function of the Gram-negative cell …

Cytoskeleton and motor proteins are required for the transcytosis of Neisseria gonorrhoeae through polarized epithelial cells

JA Wang, TF Meyer, T Rudel - International journal of medical microbiology, 2008 - Elsevier
Neisseria gonorrhoeae interact with polarized T84 epithelial cells by engaging
carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) receptors …

Biology of Neisseria gonorrhoeae and the Clinical Picture of Infection

CA Ison - Sexually transmitted infections and sexually transmitted …, 2011 - Springer
Neisseria gonorrhoeae is the causative bacterium of gonorrhoea, the second most common
bacterial sexually transmitted infection (STI). It is an obligate human pathogen and colonises …

Infection of mucosal epithelial cells by Neisseria gonorrhoeae

JPM van Putten, TD Duensing - Reviews and Research in …, 1997 - journals.lww.com
The bacterial pathogen Neisseria gonorrhoeae (gonococcus) is able to colonize and
penetrate the human mucosa, to avoid the host's defences and to persist in various …

Distinct effects of the cervicovaginal microbiota and herpes simplex type 2 infection on female genital tract immunology

B Shannon, P Gajer, TJ Yi, B Ma… - The Journal of …, 2017 - academic.oup.com
Background. Genital inflammation is a key determinant of human immunodeficiency virus
(HIV) transmission, and may increase HIV-susceptible target cells and alter epithelial …