Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Abstract In late December 2019 in Wuhan, China, several patients with viral pneumonia
were identified as 2019 novel coronavirus (2019‐nCoV). So far, there are no specific …

Respiratory disease caused by coronavirus infection remains a global health crisis.
Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available …

The cysteine protease cathepsin C (CatC) activates granule-associated proinflammatory
serine proteases in hematopoietic precursor cells. Its early inhibition in the bone marrow is …

Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be a promising …

In many respiratory diseases characterized by an intense inflammatory response, the
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors …

Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a
promising drug target for novel antivirals against SARS-CoV-2. The marine natural product …

Severe cases of pneumonia are frequently associated with acute respiratory distress
syndrome (ARDS), which carries a mortality rate of about 40%[1]. Uncontrolled host …

Inhibition of cathepsin C, a dipeptidyl peptidase that activates many serine proteases,
represents an attractive therapeutic strategy for inflammatory diseases with a high neutrophil …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …