The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
an important target for vaccine and drug development. However, the rapid emergence of …

The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens …

There is an urgent need to identify therapeutics for the treatment of Coronavirus disease
2019 (COVID-19). Although different antivirals are given for the clinical management of …

Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is
involved in microbicidal activity. NE is an important factor promoting inflammation, has …

The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms
such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have …

Introduction: The proteolytic activity of neutrophil elastase (NE) not only destroys pathogens
but also degrades host matrix tissues by generating a localized protease–antiprotease …

Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19
has spread rapidly throughout the world and poses a serious threat to public health. Acute …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

We read with great interest the editorial by Baron et al. suggesting the potential use of
teicoplanin as an alternative drug to treat patients infected with severe acute respiratory …