We read with great interest the editorial by Baron et al. suggesting the potential use of
teicoplanin as an alternative drug to treat patients infected with severe acute respiratory …

Abstract The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-
19 therapy, given its likely druggability and essentiality in the viral maturation and replication …

Cigarette smoking is a major factor for the development of pulmonary emphysema because
it induces abnormal inflammation and a protease-rich local milieu that causes connective …

Host-cell cysteine proteases play an essential role in the processing of the viral spike protein
of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that …

The fascinating similarity between the SARS-CoV and SARS-CoV-2, inspires scientific
community to investigate deeper into the SARS-CoV proteases such as main protease …

Cathepsin C is a cysteine protease required for the activation of several pro-inflammatory
serine proteases and, as such, is of interest as a therapeutic target. In cathepsin C-deficient …

The lysosomal cysteine protease cathepsin C (Cat C), also known as dipeptidyl peptidase I,
activates a number of granule-associated serine proteases with pro-inflammatory and …

The global COVID-19 coronavirus pandemic has infected over 109 million people, leading
to over 2 million deaths up to date and still lacking of effective drugs for patient treatment …

Bromhexine is an over-the-counter mucolytic cough suppressant that was introduced in
1963 under the trademark of Bisolvon®. It is a widely prescribed drug for treatment of a …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …