[HTML][HTML] A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications
Abstract As of April 20, 2020, over time, the COVID‐19 pandemic has resulted in 157 970
deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of~ 6.8%. With the …
deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of~ 6.8%. With the …
[HTML][HTML] Recent progress in the drug development targeting SARS-CoV-2 main protease as treatment for COVID-19
W Cui, K Yang, H Yang - Frontiers in molecular biosciences, 2020 - frontiersin.org
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2)
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive …
A Roghanian, JM Sallenave - Journal of aerosol medicine and …, 2008 - liebertpub.com
Proteases and antiproteases have multiple important roles both in normal homeostasis and
during inflammation. Antiprotease molecules may have developed in a parallel network …
during inflammation. Antiprotease molecules may have developed in a parallel network …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes
Background Globally, the current medical emergency for novel coronavirus 2019 (COVID-
19) leads to respiratory distress syndrome and death. Purpose This review highlighted the …
19) leads to respiratory distress syndrome and death. Purpose This review highlighted the …
Neutrophil elastase and proteinase 3 cleavage sites are adjacent to the polybasic sequence within the proteolytic sensitive activation loop of the SARS-CoV-2 spike …
Z Mustafa, A Zhanapiya, H Kalbacher, T Burster - ACS omega, 2021 - ACS Publications
Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and
neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around …
neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around …
[HTML][HTML] Drug repurposing and polypharmacology to fight SARS-CoV-2 through inhibition of the main protease
L Pinzi, A Tinivella, F Caporuscio… - Frontiers in …, 2021 - frontiersin.org
The outbreak of a new coronavirus (SARS-CoV-2), which is responsible for the COVID-19
disease and is spreading rapidly around the world, urgently requires effective therapeutic …
disease and is spreading rapidly around the world, urgently requires effective therapeutic …
[HTML][HTML] Safety and outcomes associated with the pharmacological inhibition of the kinin–kallikrein system in severe COVID-19
E Mansour, AC Palma, RG Ulaf, LC Ribeiro… - Viruses, 2021 - mdpi.com
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection
K Vandyck, J Deval - Current opinion in virology, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro) controls virus …
19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro) controls virus …
PDE4 inhibition as a therapeutic strategy for improvement of pulmonary dysfunctions in Covid-19 and cigarette smoking
C Lugnier, HM Al-Kuraishy, E Rousseau - Biochemical Pharmacology, 2021 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) is the binding-site and entry-point for
SARS-CoV-2 in human and highly expressed in the lung. Cigarette smoking (CS) is the …
SARS-CoV-2 in human and highly expressed in the lung. Cigarette smoking (CS) is the …