Epidemiological studies established an association between chronic inflammation and
higher risk of cancer. Inhibition of proteolytic enzymes represents a potential treatment …

Neutrophil granulocytes are important mediators of innate immunity, but also participate in
the pathogenesis of (auto) inflammatory diseases. Neutrophils express a specific set of …

The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …

Coronavirus disease 2019 is a major threat to public health globally. Though its
pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has …

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …

After almost two years from its first evidence, the COVID-19 pandemic continues to afflict
people worldwide, highlighting the need for multiple antiviral strategies. SARS-CoV-2 main …

The COVID-19 pandemic, which is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a public health emergency with high mortality and disability …

There are a number of respiratory diseases characterized by the presence of excess
neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chronic obstructive …

ABSTRACT The coronavirus (CoV) disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome CoV-2 (SARS-CoV-2) is a health threat worldwide. Viral main …

Highlights•The main protease, known as M pro, is encoded by the viral genome and is
essential for viral replication.•The effective target for drug development has been the M …