Stabilizing mast cells by commonly used drugs: a novel therapeutic target to relieve post-COVID syndrome?
I Kazama - Drug discoveries & therapeutics, 2020 - jstage.jst.go.jp
Regardless of the severity of coronavirus disease 2019 (COVID-19), a high proportion of
patients struggle with persistent respiratory or systemic symptoms after recovery. This is …
patients struggle with persistent respiratory or systemic symptoms after recovery. This is …
Alpha-1 antitrypsin for COVID-19 treatment: dual role in antiviral infection and anti-inflammation
Many drugs have been approved for clinical trials for the treatment of COVID-19 disease,
focusing on either antiviral or anti-inflammatory approaches. Combining antiviral and anti …
focusing on either antiviral or anti-inflammatory approaches. Combining antiviral and anti …
Treatment with an anti-CK2 synthetic peptide improves clinical response in COVID-19 patients with pneumonia. A randomized and controlled clinical trial
LR Cruz, I Baladrón, A Rittoles, PA Díaz… - ACS pharmacology & …, 2020 - ACS Publications
The instrumental role of CK2 in the SARS-CoV-2 infection has pointed out this protein
kinase as promising therapeutic target in COVID-19. Anti-SARS-CoV-2 activity has been …
kinase as promising therapeutic target in COVID-19. Anti-SARS-CoV-2 activity has been …
<? covid19?> High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
E Smith, ME Davis-Gardner… - … the Science of Drug …, 2020 - journals.sagepub.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late
2019 has triggered an ongoing global pandemic whereby infection may result in a lethal …
2019 has triggered an ongoing global pandemic whereby infection may result in a lethal …
Targeting inflammation and cytokine storm in COVID-19
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 9.2 million …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 9.2 million …
S-217622, a 3CL protease inhibitor and clinical candidate for SARS-CoV-2
JDA Tyndall - Journal of Medicinal Chemistry, 2022 - ACS Publications
The coronavirus disease (COVID-19) pandemic has highlighted the ability of scientists to
quickly react to the immense challenge presented to the world. The orally available 3CL …
quickly react to the immense challenge presented to the world. The orally available 3CL …
[HTML][HTML] Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury
The recent emergence of coronavirus disease-2019 (COVID-19) as a pandemic affecting
millions of individuals has raised great concern throughout the world, and the severe acute …
millions of individuals has raised great concern throughout the world, and the severe acute …
Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice
I Hahn, A Klaus, AK Janze, K Steinwede… - Infection and …, 2011 - Am Soc Microbiol
Neutrophil serine proteases cathepsin G (CG), neutrophil elastase (NE), and proteinase 3
(PR3) have recently been shown to contribute to killing of Streptococcus pneumoniae in …
(PR3) have recently been shown to contribute to killing of Streptococcus pneumoniae in …
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for
coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has …
coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has …
Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
Abstract Zinc pyrithione (1a), together with its analogues 1b–h and ruthenium pyrithione
complex 2a, were synthesised and evaluated for the stability in biologically relevant media …
complex 2a, were synthesised and evaluated for the stability in biologically relevant media …