Neutrophil Elastase inhibitor (Sivelestat), may be a promising therapeutic option for Management of Acute Lung Injury/acute respiratory distress syndrome or …
A Sahebnasagh, F Saghafi, M Safdari… - Authorea …, 2020 - advance.sagepub.com
This article summarizes the effects of sivelestat on ALI/ARDS or ARDS with coagulopathy,
both of which are frequently seen in patients with COVID-19. The emergence of the novel …
both of which are frequently seen in patients with COVID-19. The emergence of the novel …
Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors
M Valipour - European Journal of Medicinal Chemistry, 2022 - Elsevier
The newly emerged coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) that caused the COVID-19 pandemic, is the closest relative of SARS-CoV with high …
CoV-2) that caused the COVID-19 pandemic, is the closest relative of SARS-CoV with high …
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
V Mody, J Ho, S Wills, A Mawri, L Lawson… - Communications …, 2021 - nature.com
Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
infection is a major threat to public health. The morbidity is increasing due to lack of SARS …
infection is a major threat to public health. The morbidity is increasing due to lack of SARS …
An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19
JH Shrimp, SC Kales, PE Sanderson… - ACS pharmacology & …, 2020 - ACS Publications
SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. Consequently,
much research has gone into the development of preclinical assays for the discovery of new …
much research has gone into the development of preclinical assays for the discovery of new …
Discovery of 9, 10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19
JW Zhang, Y Xiong, F Wang, FM Zhang, X Yang… - European Journal of …, 2022 - Elsevier
The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious …
syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious …
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
D Bestle, MR Heindl, H Limburg… - Life science …, 2020 - life-science-alliance.org
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
Elafin is a neutrophil serine protease inhibitor expressed in lung and displaying anti-
inflammatory and anti-bacterial properties. Previous studies demonstrated that some innate …
inflammatory and anti-bacterial properties. Previous studies demonstrated that some innate …
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …
Human cathelicidin inhibits SARS-CoV-2 infection: killing two birds with one stone
C Wang, S Wang, D Li, P Chen, S Han… - ACS infectious …, 2021 - ACS Publications
SARS-CoV-2 infection begins with the association of its spike 1 (S1) protein with host
angiotensin-converting enzyme-2 (ACE2). Targeting the interaction between S1 and ACE2 …
angiotensin-converting enzyme-2 (ACE2). Targeting the interaction between S1 and ACE2 …
Clinical progress on management of pneumonia due to COVID-19 with Chinese traditional patent medicines
Y Wu, P Zhong - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: The outbreak of new coronavirus has tremendously threatened the public
health system worldwide, including China. Chinese patent medicines (CPMs) have greatly …
health system worldwide, including China. Chinese patent medicines (CPMs) have greatly …