Tumour‐suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model

G Topi, SR Satapathy, P Dash… - The Journal of …, 2020 - Wiley Online Library
Oestrogen receptor β (ERβ) has been suggested to have anti‐proliferative and anti‐tumour
effects in breast and prostate cancer cells, but other studies have indicated its tumour …

Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells

K Edvardsson, A Ström, P Jonsson… - Molecular …, 2011 - academic.oup.com
Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …

ERβ is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components

V Martineti, L Picariello, I Tognarini… - Endocrine-related …, 2005 - erc.bioscientifica.com
Several strands of evidence indicate that oestrogens exert a protective role against the
development of colon cancer through indirect and direct effects on colonic epithelium …

[HTML][HTML] Association of the oestrogen receptor beta with hormone status and prognosis in a cohort of female patients with colorectal cancer

G Topi, R Ehrnström, K Jirström, I Palmquist… - European journal of …, 2017 - Elsevier
Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in
the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic …

High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer

G Topi, SR Satapathy, S Ghatak, K Hellman… - Cell Communication and …, 2024 - Springer
In normal colon tissue, oestrogen receptor alpha (ERα) is expressed at low levels, while
oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon …

Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation

PA Konstantinopoulos, A Kominea, G Vandoros… - European journal of …, 2003 - Elsevier
Oestrogen Receptor β (ERβ) may protect against prostate and mammary cell proliferation
and malignant transformation. Epidemiological studies indicate that oestrogens may reduce …

Knockdown of estrogen receptor β increases proliferation and affects the transcriptome of endometrial adenocarcinoma cells

O Treeck, E Diepolder, M Skrzypczak… - BMC cancer, 2019 - Springer
Background Estrogen receptor β (ERβ) has been repeatedly suggested to play important
roles in hormone-dependent cancer like in tumors of the breast, ovary or prostate. In this …

Estrogen receptors in colorectal cancer: goalkeepers, strikers, or bystanders?

J Hartman, JÅ Gustafsson - Cancer Prevention Research, 2010 - AACR
This perspective on Jin et al.(beginning on page 910 in this issue of the journal) discusses
the importance of estrogen signaling in colorectal carcinogenesis, with a focus on estrogen …

Targeting estrogen receptors in colorectal cancer

JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …

Expression of oestrogen receptor β and prognosis of colorectal cancer

A Rudolph, C Toth, M Hoffmeister, W Roth… - British journal of …, 2012 - nature.com
Background: Previous studies suggest that sex steroids influence colorectal cancer (CRC)
carcinogenesis. The oestrogen receptor β (ERβ) is the predominantly expressed ER in the …