Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats

JM Gee, H Hara, IT Johnson - Nutrition and cancer, 2002 - Taylor & Francis
Quercetin inhibits proliferation of human gastric and colonic cancer cells in vitro by
suppressing mitosis and increasing apoptosis. Quercetin might therefore act as an …

[HTML][HTML] Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis

CA Warren, KJ Paulhill, LA Davidson, JR Lupton… - The Journal of …, 2009 - Elsevier
The flavonoid quercetin suppresses cell proliferation and enhances apoptosis in vitro. In this
study, we determined whether quercetin protects against colon cancer by regulating the …

Quercetin suppresses early colon carcinogenesis partly through inhibition of inflammatory mediators

ND Turner, KJ Paulhill, CA Warren… - … Symposium on Human …, 2007 - actahort.org
We have demonstrated that 0.45% quercetin added to a diet containing corn oil (15% w/w),
as the lipid source, and cellulose (6% w/w), as the fiber source, was able to suppress the …

Effects of quercetin and/or restraint stress on formation of aberrant crypt foci induced by azoxymethane in rat colons

Y Matsukawa, H Nishino, Y Okuyama, T Matsui… - Oncology, 1997 - karger.com
The present study examines the effect of dietary quercetin and/or restraint stress on the
formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in the colon. Female …

[HTML][HTML] Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats

AA Dihal, VCJ de Boer, H van der Woude… - The Journal of …, 2006 - Elsevier
The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers
of) colorectal cancer (CRC). Male F344 rats (n= 42/group) were fed 0, 0.1, 1, or 10 g …

Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc Min/+ Mouse

EA Murphy, JM Davis, JL McClellan… - Nutrition and …, 2011 - Taylor & Francis
Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer;
however, experimental studies in rodents are limited. Macrophages play a role in …

Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats

S Miyamoto, H Kohno, R Suzuki… - Oncology …, 2006 - spandidos-publications.com
The modifying effects of dietary feeding with chrysin (5, 7-dihydroxyflavone) on the
development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were …

Dietary quercetin, immune functions and colonic carcinogenesis in rats

JH Exon, BA Magnuson, EH South… - Immunopharmacology …, 1998 - Taylor & Francis
Rats fed 100 mg/kg quercetin (QUE) daily for 7 weeks had significantly enhanced natural
killer cell activity compared to their vehicle (VEH)-fed control. In contrast, rats fed 100 mg/kg …

Multitargeted cancer prevention by quercetin

A Murakami, H Ashida, J Terao - Cancer letters, 2008 - Elsevier
Quercetin is an anti-oxidative flavonoid widely distributed in the plant kingdom. Phenolic
hydroxyl groups at the B-ring and the 3-position are responsible for its free radical …

Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon

K Yang, SA Lamprecht, Y Liu, H Shinozaki… - …, 2000 - academic.oup.com
In this study we investigated the chemopreventive effects of quercetin and rutin when added
to standard AIN-76A diet and fed to normal and azoxymethane (AOM)-treated mice. Early …