Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway
W Hu, C Cai, Y Li, F Kang, T Chu, S Dong - The FASEB Journal, 2022 - Wiley Online Library
Osteoarthritis (OA) is a prevalent degenerative disease of the joint, featured by articular
cartilage destruction and subchondral bone marrow lesions. Articular cartilage and …
cartilage destruction and subchondral bone marrow lesions. Articular cartilage and …
Quetiapine ameliorates collagen-induced arthritis in mice via the suppression of the AKT and ERK signaling pathways
YJ Pan, WH Wang, TY Huang, WH Weng, CK Fang… - Inflammation …, 2018 - Springer
Objective and design To investigate the amelioration effects of quetiapine on rheumatoid
arthritis with RAW 264.7 macrophage and collagen-induced arthritis (CIA) DBA/1J mouse …
arthritis with RAW 264.7 macrophage and collagen-induced arthritis (CIA) DBA/1J mouse …
[HTML][HTML] Therapeutic evaluation of galangin on cartilage protection and analgesic activity in a rat model of osteoarthritis
Y Su, L Shen, J Xue, J Zou, D Wan, Z Shi - Electronic Journal of …, 2021 - Elsevier
Background Osteoarthritis (OA) is a form of arthritis due to degradation of articular cartilage.
OA is associated with stiffness, joint pain, and dysfunction, affecting adults worldwide …
OA is associated with stiffness, joint pain, and dysfunction, affecting adults worldwide …
[HTML][HTML] Bilobalide exerts anti-inflammatory effects on chondrocytes through the AMPK/SIRT1/mTOR pathway to attenuate ACLT-induced post-traumatic osteoarthritis …
T Ma, L Lv, Y Yu, L Jia, X Song, XY Xu, T Li… - Frontiers in …, 2022 - frontiersin.org
Although osteoarthritis (OA) significantly affects the quality of life of the elderly, there is still
no effective treatment strategy. The standardized Ginkgo biloba L. extract preparation has …
no effective treatment strategy. The standardized Ginkgo biloba L. extract preparation has …
Downregulating Akt/NF-κB signaling and its antioxidant activity with Loureirin A for alleviating the progression of osteoarthritis: In vitro and vivo studies
SL Hu, K Wang, YF Shi, ZX Shao, CX Zhang… - International …, 2020 - Elsevier
Osteoarthritis (OA) is one of the most common diseases in orthopedics. It is characterized by
degeneration of articular cartilage and chronic inflammation. In this study, we aim to …
degeneration of articular cartilage and chronic inflammation. In this study, we aim to …
Protective effects of piperlongumine against adjuvant-induced arthritis in rats through modulating OPG/RANKL/NF-κB signaling pathway
S Wu, X Wu, T Wang, F Jiang, M Hu, R Li… - Journal of Pharmacy …, 2024 - academic.oup.com
Objectives We examined the antirheumatoid effects of piperlongumine (PLM) on rat adjuvant-
induced arthritis (AIA) and explored the underlying mechanisms involved. Methods PLM …
induced arthritis (AIA) and explored the underlying mechanisms involved. Methods PLM …
Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway
Y Jia, C Pang, K Zhao, J Jiang, T Zhang, J Peng, P Sun… - Inflammation, 2019 - Springer
Osteoarthritis (OA), which is characterized as a common degenerative joint disease, is
presently the most prevalent chronic degenerative joint disease. Accumulating evidence has …
presently the most prevalent chronic degenerative joint disease. Accumulating evidence has …
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis
Y Li, J Wu, N Zhuo - Experimental and Therapeutic …, 2023 - spandidos-publications.com
Ginsenoside compound K (GCK) has been previously reported to be a potent antiarthritic
and bone‑protective agent. Therefore, the present study aimed to explore the potential …
and bone‑protective agent. Therefore, the present study aimed to explore the potential …
[HTML][HTML] Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway
Q Fu, Y Gao, H Zhao, Z Wang… - Molecular Medicine …, 2018 - spandidos-publications.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease that significantly affects patient
quality of life. Galangin is an extract with multiple health benefits, including anti‑oxidative …
quality of life. Galangin is an extract with multiple health benefits, including anti‑oxidative …
Cathelicidin-BF regulates the AMPK/SIRT1/NF-κB pathway to ameliorate murine osteoarthritis: In vitro and in vivo studie
H Zhou, L Zou, H Ren, Z Shen, Y Lin, H Cai… - International …, 2024 - Elsevier
Osteoarthritis (OA) is a chronic degenerative disease with a significant prevalence that
causes cartilage damage and can lead to disability. The main factors contributing to the …
causes cartilage damage and can lead to disability. The main factors contributing to the …