Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages
L Ni, Z Lin, S Hu, Y Shi, Z Jiang, J Zhao, Y Zhou… - Biochemical …, 2022 - Elsevier
Osteoarthritis (OA) is a progressive joint disease characterized by the degradation and
destruction of articular cartilage, which is involved with pathological microenvironmental …
destruction of articular cartilage, which is involved with pathological microenvironmental …
Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes
W Zheng, H Pan, L Wei, F Gao, X Lin - International Immunopharmacology, 2019 - Elsevier
Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic
inflammation, the formation of an invasive pannus, and destruction of the joints. In the …
inflammation, the formation of an invasive pannus, and destruction of the joints. In the …
[HTML][HTML] Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis
J Zhang, S Wang, G Rong… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis (OA) is a highly prevalent disease, which is associated with extracellular
matrix degradation and cell death in articular cartilage. The aim of the present study was to …
matrix degradation and cell death in articular cartilage. The aim of the present study was to …
Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway
H Wu, M Zhang, W Li, S Zhu, D Zhang - Chemico-biological interactions, 2020 - Elsevier
Osteoarthritis (OA) is a common degenerative joint disease that is closely associated with
inflammation. Stachydrine (STA) is a bioactive alkaloid with anti-inflammatory activity …
inflammation. Stachydrine (STA) is a bioactive alkaloid with anti-inflammatory activity …
[HTML][HTML] Salidroside promotes osteoblast proliferation and differentiation via the activation of AMPK to inhibit bone resorption of knee osteoarthritis mice
S Fu, M Yan, Q Fan, J Xu - Tissue and Cell, 2022 - Elsevier
Aim Balance between osteoclasts and osteoblasts was important for bone development and
regeneration, which attracted wide attention. To investigate whether the pro-restorative effect …
regeneration, which attracted wide attention. To investigate whether the pro-restorative effect …
[HTML][HTML] Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway
C Lu, Y Li, S Hu, Y Cai, Z Yang, K Peng - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that is commonly accompanied by
inflammation. Scoparone is a biologically active constituent isolated from Artemisia capillaris …
inflammation. Scoparone is a biologically active constituent isolated from Artemisia capillaris …
Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis
R Li, L Cai, J Ding, C Hu, T Wu… - Journal of Pharmacy and …, 2015 - academic.oup.com
Objectives We investigated whether inhibition of hedgehog (Hh) signal by cyclopamine
attenuated inflammation and cartilage damage in adjuvant-induced arthritis (AIA) rats …
attenuated inflammation and cartilage damage in adjuvant-induced arthritis (AIA) rats …
[HTML][HTML] The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro
H Zhang, L Ji, Y Yang, Y Wei, X Zhang, Y Gang… - Frontiers in …, 2019 - frontiersin.org
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone
deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the …
deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the …
The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow …
JE Huh, IT Jung, J Choi, YH Baek, JD Lee… - European journal of …, 2013 - Elsevier
We investigated the effect of galangin, a natural flavonoid, on osteoclastic bone destruction
in collagen-induced arthritis and examined the molecular mechanisms by which galangin …
in collagen-induced arthritis and examined the molecular mechanisms by which galangin …