Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
M Jastroch, KW Withers, S Taudien… - Physiological …, 2008 - journals.physiology.org
Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive
nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the …
nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the …
Absence of adaptive nonshivering thermogenesis in a marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata)
ET Polymeropoulos, M Jastroch, PB Frappell - Journal of Comparative …, 2012 - Springer
The presence of nonshivering thermogenesis in marsupials is controversially debated.
Survival of small eutherian species in cold environments is crucially dependent on …
Survival of small eutherian species in cold environments is crucially dependent on …
Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials
M Jastroch, ET Polymeropoulos, MJ Gaudry - Journal of Comparative …, 2021 - Springer
The thermogenic mechanisms supporting endothermy are still not fully understood in all
major mammalian subgroups. In placental mammals, brown adipose tissue currently …
major mammalian subgroups. In placental mammals, brown adipose tissue currently …
Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny
MJ Gaudry, KL Campbell - Frontiers in physiology, 2017 - frontiersin.org
Uncoupling protein 1 (UCP1) permits non-shivering thermogenesis (NST) when highly
expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals …
expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals …
Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
S Saito, CT Saito, R Shingai - Gene, 2008 - Elsevier
Homeotherms possess various physiological mechanisms to maintain their body
temperature, thus allowing them to adapt to various environments. Under cold conditions …
temperature, thus allowing them to adapt to various environments. Under cold conditions …
Disruption of thermogenic UCP1 predated the divergence of pigs and peccaries
TJ Fyda, C Spencer, M Jastroch… - Journal of …, 2020 - journals.biologists.com
ABSTRACT Uncoupling protein 1 (UCP1) governs non-shivering thermogenesis in brown
adipose tissue. It has been estimated that pigs lost UCP1∼ 20 million years ago (MYA) …
adipose tissue. It has been estimated that pigs lost UCP1∼ 20 million years ago (MYA) …
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes
S McGaugh, TS Schwartz - Biology letters, 2017 - royalsocietypublishing.org
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian
mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although …
mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although …
Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades
Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in
brown adipose tissue and is widely accepted to have played a key thermoregulatory role in …
brown adipose tissue and is widely accepted to have played a key thermoregulatory role in …
Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis
Uncoupling proteins (UCPs) increase proton leakage across the inner mitochondrial
membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat …
membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat …
Two-stage evolution of mammalian adipose tissue thermogenesis
Brown adipose tissue (BAT) is a heater organ that expresses thermogenic uncoupling
protein 1 (UCP1) to maintain high body temperatures during cold stress. BAT thermogenesis …
protein 1 (UCP1) to maintain high body temperatures during cold stress. BAT thermogenesis …