Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

Ying Yang 1 (YY1) is a ubiquitously expressed transcription factor shown to be essential for
pro–B-cell development. However, the role of YY1 in other B-cell populations has never …

YB-1 is a broad-specificity RNA-binding protein that is involved in regulation of mRNA
transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and …

Current models of translational regulation are mostly focused on how translational factors
engage a messenger mRNA to the ribosome to initiate translation. Since the majority of …

Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

Y-box protein-1 involvement in cyclin A and B1 gene regulation has recently been
demonstrated. A more generalized role of this protein for cell replication is hypothesized as …

The multifunctional Y box-binding protein 1 (YB-1) is transcriptionally repressed by the
oncogenic phosphoinositide 3-kinase (PI3K) pathway (with P3K as an oncogenic homolog …

Members of the Y-box (YB) family of transcription factors are expressed in a wide range of
cell types and are implicated in the regulation of a rapidly increasing number of genes …

The Y box is an important sequence motif found in promoters and enhancers containing a
CCAAT box–one of the few elements enriched in promoters of large sets of genes …

During B cell development, long-distance DNA interactions are needed for V (D) J somatic
rearrangement of the immunoglobulin (Ig) loci to produce functional Ig genes, and for class …