Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive
decline. Amyloid plaque deposits consisting specifically of β‐amyloid peptides that have …

C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein known to be expressed in brain of Alzheimer's disease (AD) patients …

C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein of the immune system that has been shown to be expressed in the …

Complement has been postulated to contribute to inflammatory reactions associated with the
neuropathology of Alzheimer's disease (AD). C1q, an initial component of the complement …

In transgenic models of Alzheimer's disease (AD) neuronal loss has not been widely
observed. The loss of neurons in AD may be due to chronic activation of complement (C') by …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's
disease probably result from direct binding and activation of C1 by amyloid β peptides. RT …

Amyloid β peptide (Aβ) is a major component of senile plaques, one of the principle
pathological features in Alzheimer's disease (AD) brains. Fibrillar Aβ has been shown to …

Background Complement proteins and activation products have been found associated with
neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was …

The complement protein, C1q, has been shown to bind to fibrillar β-amyloid, resulting in the
activation of the classical complement pathway. C1q has also been found associated with …