Challenge tests stress homeostasis and may reveal deviations in health that remain masked
under unchallenged conditions. Ideally, challenge tests are non-invasive and applicable in …

Obesity is a metabolic disease that is accompanied by oxidative stress. Mitochondrial
dysfunction is closely associated with the occurrence and development of obesity. However …

Metabolic flexibility is defined as the ability to adapt substrate oxidation rates in response to
changes in fuel availability. The inability to switch between the oxidation of lipid and …

Obesity is associated with white adipose tissue (WAT) hypoxia and inflammation. We aimed
to test whether mild environmental oxygen restriction (OxR, 13% O2), imposing tissue …

Aim We tested the hypothesis that low testosterone alters the effects of intermittent hypoxia
(IH) on glucose homeostasis, hepatic oxidative stress, and transcriptomic profile in male …

Decreased metabolic flexibility, ie a compromised ability to adjust fuel oxidation to fuel
availability supports development of adverse consequences of obesity. The aims of this …

Blood glucose and the prevalence of diabetes are lower in mountain than lowland dwellers,
which could among other factors be due to reduced oxygen availability. To investigate …

Objective High levels of reactive oxygen species (ROS) are intricately linked to obesity and
associated pathologies, notably insulin resistance and type 2 diabetes. However, ROS are …

First conceptualized from breath‐hold diving mammals, later recognized as the ultimate cell
autonomous survival strategy in anoxia‐tolerant vertebrates and burrowing or hibernating …

Objective Recent studies suggest that hypoxia exposure may improve glucose homeostasis,
but well-controlled human studies are lacking. We hypothesized that mild intermittent …