Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive
oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a …

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in the
Western world, with limited treatment opportunities. 3, 5, 7, 4′-Tetrahydroxyflavanone …

Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has
been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention …

Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …

Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …

Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …

Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from
drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of …

The common analgesic acetaminophen (N-acetyl-p-aminophenol, APAP) is non-toxic to the
liver at therapeutic doses. However, an overdose of APAP can lead to APAP-induced liver …