Astrocytes undergo an inflammatory transition after infections, acute injuries and chronic
neurodegenerative diseases. How this transition is affected by time and sex, its …

Astrocytic contributions to neuroinflammation are widely implicated in disease, but they
remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex …

Astrocytes fulfil many functions in the central nervous system (CNS), including contribution to
the blood brain barrier, synapse formation, and trophic support. In addition, they can mount …

Inflammation features in CNS disorders such as stroke, trauma, neurodegeneration,
infection, and autoimmunity in which astrocytes play critical roles. To elucidate how …

Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …

Astroglia is well-known to be integrated in the complex regulation of neuroinflammation in
the central nervous system. Astrocytes become activated and synthesize cytokines …

Background Neuronal damage in acute CNS injuries and chronic neurodegenerative
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …

Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …