Neuroinflammatory astrocyte subtypes in the mouse brain
Astrocytes undergo an inflammatory transition after infections, acute injuries and chronic
neurodegenerative diseases. How this transition is affected by time and sex, its …
neurodegenerative diseases. How this transition is affected by time and sex, its …
[HTML][HTML] Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation
B Diaz-Castro, AM Bernstein, G Coppola… - Cell reports, 2021 - cell.com
Astrocytic contributions to neuroinflammation are widely implicated in disease, but they
remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex …
remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex …
Regionally diverse astrocyte subtypes and their heterogeneous response to EAE
M Borggrewe, C Grit, ID Vainchtein, N Brouwer… - Glia, 2021 - Wiley Online Library
Astrocytes fulfil many functions in the central nervous system (CNS), including contribution to
the blood brain barrier, synapse formation, and trophic support. In addition, they can mount …
the blood brain barrier, synapse formation, and trophic support. In addition, they can mount …
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors
ME Hamby, G Coppola, Y Ao… - Journal of …, 2012 - Soc Neuroscience
Inflammation features in CNS disorders such as stroke, trauma, neurodegeneration,
infection, and autoimmunity in which astrocytes play critical roles. To elucidate how …
infection, and autoimmunity in which astrocytes play critical roles. To elucidate how …
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Astrocytes: key regulators of neuroinflammation
E Colombo, C Farina - Trends in immunology, 2016 - cell.com
Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
Brain-region-specific astroglial responses in vitro after LPS exposure
M Kipp, A Norkute, S Johann, L Lorenz, A Braun… - Journal of Molecular …, 2008 - Springer
Astroglia is well-known to be integrated in the complex regulation of neuroinflammation in
the central nervous system. Astrocytes become activated and synthesize cytokines …
the central nervous system. Astrocytes become activated and synthesize cytokines …
[HTML][HTML] Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
Background Neuronal damage in acute CNS injuries and chronic neurodegenerative
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …
[HTML][HTML] Astrocyte crosstalk in CNS inflammation
M Linnerbauer, MA Wheeler, FJ Quintana - Neuron, 2020 - cell.com
Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …
clear that specific astrocyte subsets or activation states are associated with specific genomic …
[HTML][HTML] Exposure to inflammatory cytokines IL-1β and TNFα induces compromise and death of astrocytes; implications for chronic neuroinflammation
C van Kralingen, DT Kho, J Costa, CE Angel… - PloS one, 2013 - journals.plos.org
Background Astrocytes have critical roles in the human CNS in health and disease. They
provide trophic support to neurons and are innate-immune cells with keys roles during states …
provide trophic support to neurons and are innate-immune cells with keys roles during states …