Cytogenetics can inform risk stratification in pediatric acute myeloid leukemia (AML). We
describe the first case of a newborn with leukemia cutis found to have AML harboring a …

Mixed lineage leukemia [MLL; now known as lysine methyltransferase 2A (KMT2A)]
rearrangement-positive acute myeloid leukemia (AML) and juvenile myelomonocytic …

Chimeric fusion genes are highly prevalent in childhood acute leukemia and have been
recognized as causal events in the process of leukemic transformation. Infant leukemia, for …

Acute myeloid leukemia (AML) is a heterogeneous disease with known specific recurrent
genetic aberrations. The continuous and increasing identification of new genetic lesions has …

Chromosome translocations that result in gene fusion and expression of the fusion gene
products are frequently observed in acute myeloid leukemia (AML). The recurrent …

Background Acute myeloid leukemia (AML) with megakaryocytic differentiation (AMkL) is a
rare subtype of AML more common in children. Recent literature has identified multiple …

CBFβ-MYH11 fusion transcripts are expressed in acute myeloid leukemias of the M4Eo
subtype. Patients who express CBFβ-MYH11 fusion transcripts respond favorably to high …

Specific gene rearrangements seem to distinguish distinct subsets of acute myeloid
leukaemia (AML) with different features and prognosis, and some reports suggest that the …

The inv (16)(p13q22) rearrangement is present in approximately 10% of cases with de novo
acute myeloid leukemia (AML) and results in a CBFB-MYH11 gene fusion. 1 Patients with …

Background. Lysine methyltransferase 2A (KMT2A) rearrangements are commonly found in
juvenile acute myeloid leukaemia (AML). Although distinct diseases, there is a known …