Anaplastic lymphoma receptor tyrosine kinase (ALK) is located on chromosome 2p23; the
chromosomal rearrangements of this gene are common genetic alterations, resulting in the …

Translocation (10; 17)(p15; q21) is a recurrent abnormality that has been reported in only
seven cases of acute leukemia, including two by our group [1](available at: http://cgap. nci …

Abstract The t (8; 16)(p11; p13) fuses the MOZ (MYST3) gene at 8p11 with CBP (CREBBP)
at 16p13 and is associated with an infrequent but well‐defined type of acute myeloid …

Background and Aims The biological characterization of childhood acute myeloid leukemia
(c-AML) is an important outcome predictor. In Brazil, very little is known about the frequency …

Background Chromosome abnormalities often occur prenatally in childhood leukemia,
characterizing an early event in leukemogenesis. The majority of the abnormalities occurring …

The MLL gene at 11q23 is a site of frequent rearrangement in acute leukemia with multiple
fusion partners. A relatively uncommon rearrangement, associated with infant AML-M4 …

The histone methyltransferase gene EZH2 (enhancer of zeste homolog 2) is the catalytic
subunit of the PRC2 polycomb complex and mediates transcriptional repression through its …

Background and aims: The objectives of this study were to investigate the cyto-molecular
profile and survival of pediatric acute myeloid leukemia (AML). Methods: This prospective …

Patients with various hematologic malignancies, including acute lymphoblastic leukemia
(ALL), acute myeloblastic leukemia (AML), diffuse histiocytic lymphoma, and granulocytic …

The cytogenetic findings in acute myeloid leukemia (AML) are a powerful prognostic
indicator. Among these abnormalities, the World Health Organization has classified inv …