Purpose: The deleterious effects of benzalkonium chloride (BAK) on the ocular surface are
well known. However, few clinical data are available to prove a toxic effect at the level of the …

Objective To investigate the effects of timolol maleate with preservative and its preserved
(PV) and nonpreserved vehicles (NPV)(benzalkonium chloride) on the blood-aqueous …

Objective To assess the impact of long-term treatment with topical timolol on bronchial
reactivity in healthy individuals. Methods Twenty-one otherwise healthy individuals with high …

Introduction The aim of this study was to comparatively analyze the effects of topical
intraocular pressure (IOP)-lowering drugs on the ocular surface and to elucidate whether the …

• We conducted a randomized, double-masked, long-term clinical trial to determine whether
topical timolol therapy was effective in delaying or preventing the onset of glaucomatous …

PURPOSE: We evaluated the anterior segment surface reaction findings between timolol
hemihydrate and timolol maleate. The only known difference between these preparations is …

Background: There is evidence that the ocular hypotensive effect of topical betablockers
persists for at least 24 hours once beta-blockade has been achieved. In previous studies …

Purpose: To determine whether there were ocular surface changes in glaucomatous
patients treated with preservatives beta-blockers who switched to preservative-free beta …

Benzalkonium chloride (BAK) is the principal preservative employed in topical ocular
hypotensive medications, although alternative compounds recently have begun to be …

Purpose: To evaluate the effects of benzalkonium chloride (BAK) on the blood–aqueous
(BAB) and blood–retinal barriers (BRB) of pseudophakic eyes. Methods: Prospective …