In vitro morphogenesis and differentiation of human intestinal epithelium in a gut-on-a-chip
The establishment of a three-dimensional (3D) epithelial structure and cytodifferentiation in
vitro is necessary to recapitulate in vivo-relevant structure and function of the human …
vitro is necessary to recapitulate in vivo-relevant structure and function of the human …
[HTML][HTML] 3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …
organized crypt–villus characteristics. This unique structure is necessary to maintain …
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Existing in vitro models of human intestinal function commonly rely on use of established
epithelial cell lines, such as Caco-2 cells, which form polarized epithelial monolayers but fail …
epithelial cell lines, such as Caco-2 cells, which form polarized epithelial monolayers but fail …
Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
I Nagao, M Nakazawa, YM Ambrosini - JoVE (Journal of Visualized …, 2024 - jove.com
Canine intestines possess similarities in anatomy, microbiology, and physiology to those of
humans, and dogs naturally develop spontaneous intestinal disorders similar to humans …
humans, and dogs naturally develop spontaneous intestinal disorders similar to humans …
Single-cell transcriptomics elucidates in vitro reprogramming of human intestinal epithelium cultured in a physiodynamic gut-on-a-chip
The microphysiological human gut-on-a-chip has demonstrated in vivo-relevant cellular
fidelity of intestinal epithelium compared to its cultures in a static condition,. Microfluidic …
fidelity of intestinal epithelium compared to its cultures in a static condition,. Microfluidic …
[HTML][HTML] Organ-on-chip approaches for intestinal 3D in vitro modeling
The intestinal epithelium has one of the highest turnover rates in the human body, which is
supported by intestinal stem cells. Culture models of intestinal physiology have been …
supported by intestinal stem cells. Culture models of intestinal physiology have been …
Advances in reconstructing intestinal functionalities in vitro: from two/three dimensional-cell culture platforms to human intestine-on-a-chip
Standard two/three dimensional (2D/3D)-cell culture platforms have facilitated the
understanding of the communications between various cell types and their …
understanding of the communications between various cell types and their …
[HTML][HTML] Bioengineered human colon organoids with in vivo-like cellular complexity and function
Organoids and organs-on-a-chip have emerged as powerful tools for modeling human gut
physiology and disease in vitro. Although physiologically relevant, these systems often lack …
physiology and disease in vitro. Although physiologically relevant, these systems often lack …
[HTML][HTML] Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip
MS Jeon, YY Choi, SJ Mo, JH Ha, YS Lee, HU Lee… - Nano …, 2022 - Springer
The intestinal microbiome affects a number of biological functions of the organism. Although
the animal model is a powerful tool to study the relationship between the host and microbe …
the animal model is a powerful tool to study the relationship between the host and microbe …
Combining human organoids and organ-on-a-chip technology to model intestinal region-specific functionality
The intestinal mucosa is a complex physical and biochemical barrier that fulfills a myriad of
important functions. It enables the transport, absorption, and metabolism of nutrients and …
important functions. It enables the transport, absorption, and metabolism of nutrients and …