Beta-cell-specific expression of nicotinamide adenine dinucleotide phosphate oxidase 5 aggravates high-fat diet-induced impairment of islet insulin secretion in mice
K Bouzakri, C Veyrat-Durebex, C Holterman… - Antioxidants & redox …, 2020 - liebertpub.com
Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …
Nicotinamide adenine dinucleotide phosphate oxidases in glucose homeostasis and diabetes-related endothelial cell dysfunction
OI Brown, KI Bridge, MT Kearney - Cells, 2021 - mdpi.com
Oxidative stress within the vascular endothelium, due to excess generation of reactive
oxygen species (ROS), is thought to be fundamental to the initiation and progression of the …
oxygen species (ROS), is thought to be fundamental to the initiation and progression of the …
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
N Li, B Li, T Brun, C Deffert-Delbouille, Z Mahiout… - Diabetes, 2012 - Am Diabetes Assoc
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …
been reported, along with controversial findings regarding its function. Here, the role of …
Suppression of NADPH oxidase 2 substantially restores glucose‐induced dysfunction of pancreatic NIT‐1 cells
H Yuan, Y Lu, X Huang, Q He, Y Man, Y Zhou… - The FEBS …, 2010 - Wiley Online Library
Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
E Anvari, P Wikström, E Walum, N Welsh - Free radical research, 2015 - Taylor & Francis
In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …
NADPH oxidase 4 in mouse β cells participates in inflammation on chronic nutrient overload
B Holendová, Š Benáková, M Křivonosková… - …, 2024 - Wiley Online Library
Objective By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4,
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …
Role of insulin-induced reactive oxygen species in the insulin signaling pathway
Oxidants, including hydrogen peroxide (H2O2), have been recognized for years to mimic
insulin action on glucose transport in adipose cells. Early studies also demonstrated the …
insulin action on glucose transport in adipose cells. Early studies also demonstrated the …
NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice
AH de Souza, LRB Santos, LP Roma… - Molecular and cellular …, 2017 - Elsevier
High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes
A Kowluru, RA Kowluru - Biochemical pharmacology, 2014 - Elsevier
Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …
Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines
J Weaver, DA Taylor-Fishwick - Biochemical and biophysical research …, 2017 - Elsevier
Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …