Keeping the heart healthy: the role of exercise in cardiac repair and regeneration

J Jiang, L Ni, X Zhang, E Chatterjee… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Heart failure is often accompanied by a decrease in the number of
cardiomyocytes. Although the adult mammalian hearts have limited regenerative capacity …

Molecular mechanisms of cardiac remodeling and regeneration in physical exercise

D Schüttler, S Clauss, LT Weckbach, S Brunner - Cells, 2019 - mdpi.com
Regular physical activity with aerobic and muscle-strengthening training protects against the
occurrence and progression of cardiovascular disease and can improve cardiac function in …

The molecular mechanisms associated with aerobic exercise-induced cardiac regeneration

B Bo, Y Zhou, Q Zheng, G Wang, K Zhou, J Wei - Biomolecules, 2020 - mdpi.com
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes.
Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly …

The regulatory role of oxygen metabolism in exercise-induced cardiomyocyte regeneration

B Bo, S Li, K Zhou, J Wei - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and
is therefore unable to generate adequate cardiac output. Previous research has …

Hallmarks of exercised heart

Y Qiu, X Pan, Y Chen, J Xiao - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
The benefits of exercise in humans on the heart have been well recognized for many years.
Long-term endurance exercise training can induce physiologic cardiac hypertrophy with …

Exercise-induced adult cardiomyocyte proliferation in mammals

G Zhang, M Sun, X Zhang - Frontiers in Physiology, 2021 - frontiersin.org
Loss of cardiomyocytes is a vital manifestation and predisposing factor of many
cardiovascular diseases and will eventually lead to heart failure (HF). On the other hand …

The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling

H Gao, Z Li, L Gan, X Chen - Journal of Cardiovascular Translational …, 2024 - Springer
Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary
prevention and treatment of cardiovascular diseases, effectively ameliorating cardiac …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

Formation of new cardiomyocytes in exercise

L Shen, H Wang, Y Bei, D Cretoiu, SM Cretoiu… - … Disease Prevention and …, 2017 - Springer
Heart failure is a life-threatening disorder associated with the loss of cardiomyocytes. The
heart has some endogenous although limited regenerative capacity, thus enhancing cardiac …

Exercise as a platform for pharmacotherapy development in cardiac diseases

Y Bei, Q Zhou, Q Sun, J Xiao - Current pharmaceutical design, 2015 - ingentaconnect.com
Moderate exercise is an effective and economic way to prevent and treat cardiovascular
diseases. Unlike pathological cardiac growth, exercise-induced cardiac growth, excluding …