BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …

AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …

Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …

It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced
in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we …

Background & Aims: Following hepatic injury, hepatic stellate cells (HSCs) transdifferentiate
to become extracellular matrix-producing myofibroblasts and to promote hepatic …

Aim: During fibrosis, hepatic stellate cells (HSCs) undergo a complex activation process
characterized by increased proliferation and extracellular matrix deposition. Previous …

Abstract Background/Aims: It is known that the activation of hepatic stellate cells (HSCs) is a
pivotal step in the initiation and progression of liver fibrosis. Aberrant activated Wnt/β-catenin …