THE proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine
osteosarcoma1. Fos protein is a major component of the AP-1 transcription factor complex …

The phylogenic conservation of the proto-oncogene c-fos suggests that this gene product is
required for normal metabolic processes. Investigations into the transcription pattern of c-fos …

Transgenic mice were generated expressing c-fos genes under the control of the human
metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in …

Osteoclasts are bone-resorbing cells derived from haematopoietic precursors of the
monocyte-macrophage lineage. Mice lacking Fos (encoding c-Fos) develop osteopetrosis …

THE development of a multicellular organism involves a delicate balance among the
processes of proliferation, differentiation and death. Naturally occurring cell death aids …

Gene expression is modulated by the specific interactions of nuclear proteins with unique
regulatory sequences in the genome. Proteins involved in transcriptional regulation seem to …

We have generated transgenic mice expressing the proto-oncogene c-fos from an H-2Kb
class I MHC promoter as a tool to identify and isolate cell populations which are sensitive to …

PROTO-ONCOGENE fos encodes a nuclear phosphoprotein of 380 amino acids that can
modulate the transcription of other genes either by transactivation or by transrepression1-7 …

The c-fos proto-oncogene has been implicated as a central regulatory component of the
nuclear response i: o mitogens and other extracellular stimuli. Embryonic stem cells targeted …

The proto-oncogene transcription factors Fos and Jun form a heterodimeric complex that
binds to DNA and regulates expression of specific target genes. Continuous expression of c …