Transgenic mice overexpressing the c-fos proto-oncogene in bone develop osteosarcomas,
whereas mice overexpressing c-Jun are normal. In this study, we investigated whether Fos …

Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine
residues stabilizes the interaction between the fos and jun proteins. We show that the …

Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells
results in expression of c-fos mRNA and protein. This is accompanied by the appearance of …

cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human
c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that …

Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-
Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that …

Members of the AP-1 family of transcription factors participate in the regulation of bone cell
proliferation and differentiation. We report here a potent AP-1-related regulator of osteoblast …

We have generated monoclonal antibodies by using a synthetic peptide corresponding to
amino acid positions 4 to 17 of the human fos protein. The antibodies detected both v-and c …

The Fos and Jun oncoproteins form dimeric complexes that stimulate transcription of genes
containing activator protein–1 regulatory elements. We found, by representational difference …

The proto-oncogenes c-fos and c-jun function cooperatively as inducible transcription factors
in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric …

Before quiescent cells can respond to mitogens and progress through the G1 phase of cell
growth, new messenger RNA synthesis is required1. The G1 phase seems to be a critical …