THE protein products of the c-fos and c-jun proto-oncogenes (Fos and Jun, respectively)
form a heterodimeric protein complex that interacts with the activator protein-1 (AP-1) …

Cellular genes containing nucleotide sequences homologous to retroviral oncogenes (v-
onc) have been identified in the genomes of a variety of species of both the vertebrate and …

THE proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of
the avian sarcoma virus 17 (ref. 1). c-jun encodes one major component of the AP-1 …

Developmental studies of oncogene expression and transgenic animal studies implicate c-
fos and other fos and jun family members in the regulation of bone tissue formation …

Vertebrate embryologists are beginning to understand the early development decisions that
control the origin and patterning of skeletal elements. However, the regulators governing the …

Expression of the c-fos proto-oncogene has been associated with mitosis or differentiation in
a number of tissue culture model systems. We have studied the expression of this gene …

TRANSCRIPTION of the proto-oncogene c-fos is stimulated rapidly and transiently by serum
growth factors and mitogens1. Critical for this response is the serum-response element …

THE AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun
and c-Fos1, controls the stimulation of cellular genes by growth factors and the expression of …

THE products of the cellular and retroviral fos genes associate with other nuclear proteins1,
2, among them the transcription factor APl/Jun (see ref. 3 for a review). The Fos/Jun complex …

Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast
activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of …