Jun and Fos oncoproteins form a complex that regulates transcription from promoters
containing AP-1 binding sites. The'leucine zipper'domain of both Fos and Jun is necessary …

Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content,
and osteoclast activity were investigated in the hematopoietic organs of the colony …

Mice that are mutant at the op locus have a severe deficiency of mononuclear phagocytes
due to an inactivating mutation in the CSF-1 (macrophage colony-stimulating factor, M-CSF) …

Publisher Summary This chapter discusses the recent advances in the understanding of
cellular gene regulation by c-fos—the cellular homolog of the transforming gene (v-fos) of …

Summary The adipocyte P2 (aP2) gene contains a regulatory element, FSE2, that functions
during adipocyte differentiation and binds a protein complex containing the product of the …

RAPID, transient induction of the human c-fos proto-oncogene by extracellular signals
requires the presence in els of the serum response element (SRE) 1, 2. Two protein factors …

The expression of different members of the Jun and Fos families of transcription factors is
rapidly induced following serum stimulation of quiescent fibroblasts. To determine whether …

Background Fibrous dysplasia is characterized by intense marrow fibrosis and increased
rates of bone turnover. The lesions of fibrous dysplasia resemble those described in the long …

The proteins encoded by the proto-oncogenes c-fos and c-jun (Fos and Jun, respectively)
form a heterodimeric complex that regulates transcription by interacting with the DNA …

Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction
of expression of both c-fos mRNA and protein within a few minutes, followed by activation of …