METHODS: Genetic analyses using genome-wide single nucleotide polymorphism
genotyping and whole exome sequencing were performed to calculate weighted genetic risk …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

OBJECTIVES: Estimates of familial risk of inflammatory bowel diseases (IBDs), Crohn's
disease (CD), and ulcerative colitis (UC) are needed for counseling of patients and could be …

Pediatric-onset inflammatory bowel disease (IBD) is characterized by distinct phenotypic
differences compared to adult-onset IBD. This raises the question whether early (pediatric) …

Initial reports of familial clustering of inflammatory bowel disease (IBD), ie, families with
multiple relatives with Crohn's disease (CD) or ulcerative colitis (UC), suggested that these …

Background: Our aim was to characterize the biochemical markers at diagnosis in patients
with inflammatory bowel disease (IBD), to assess the utility of these to predict disease …

The role of a positive family history in pediatric inflammatory bowel disease (IBD) in the era
of biologic therapy has not been elucidated. We retrospectively reviewed the medical …

Both Crohn's disease and ulcerative colitis occur frequently in the pediatric age group, with a
peak incidence in the second decade of life. Approximately 25% of patients with these …

METHODS: Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was
estimated by polygenic risk scores and further categorized into high, intermediate, and low …

Background: Crohn's disease (CD) may progress from an inflammatory to a stricturing or
penetrating disease phenotype. The aim of our study was to identify single nucleotide …