Cumulative T-cell receptor signal strength and ensuing T-cell responses are affected by both
antigen affinity and antigen dose. Here we examined the distinct contributions of these …

Many studies have examined pathways controlling effector T cell differentiation, but less is
known about the fate of individual CD8+ T cells during infection. Here, we examine the …

In response to acute infections or vaccines, naive antigen‐specific CD8+ T cells proliferate
and differentiate into effector cytotoxic lymphocytes that acquire the ability to kill infected …

Naïve CD4+ T cells undergo massive cell proliferation upon encountering their cognate
ligand. This proliferation depends upon appropriate cues from the antigen-presenting cells …

Through genetic recombination, the adaptive immune system generates a diverse T cell
repertoire allowing recognition of a vast spectrum of foreign antigens. Any given CD8+ T cell …

A hallmark of adaptive immunity is CD4 T cells' ability to differentiate into specialized
effectors. A long-standing question is whether T cell receptor (TCR) signal strength can …

The initiation of a T‐cell response begins with the interaction of an individual T‐cell clone
with its cognate antigen presented by MHC. Although the strength of the T‐cell receptor …

CD4+ T cell responses are composed of heterogeneous T cell receptor (TCR) signals that
influence the acquisition of effector and memory characteristics. We sought to define early …

During CD4+ T cell activation, T cell receptor (TCR) signals impact T cell fate, including
recruitment, expansion, differentiation, trafficking, and survival. To determine the impact of …

Factors that influence T cell responses, such as Ag load, APCs, costimulatory molecules,
and cytokines, dramatically change during the course of an immune response. We observed …