With an overall prevalence of 10–20%, gallstone disease (cholelithiasis) represents one of
the most frequent and economically relevant health problems of industrialized countries,. We …

Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …

Genomewide scans of inbred strains of mice have linked the genes encoding the
hepatocanalicular cholesterol transporter ABCG5/G8 to gallstone formation. Five …

Katsika D, Magnusson P, Krawczyk M, Grünhage F, Lichtenstein P, Einarsson C, Lammert F,
Marschall H‐U (Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm …

Background Gallstone disease (GD) belongs to the most frequent disorders in
gastroenterology and causes high costs in our health‐care systems. Gallstones are …

The sterolin locus (ABCG5/ABCG8) confers susceptibility for cholesterol gallstone disease in
humans. Both the responsible variant and the molecular mechanism causing an increased …

Cholestatic liver diseases are caused by a range of hepatobiliary insults and involve
complex interactions among environmental and genetic factors. Little is known about the …

Background Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and
ABCG8 are sterol export pumps regulating biliary cholesterol excretion. The formation of …

Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …

ATP-binding cassette (ABC) transporters function in the homeostasis of lipids. Dysfunction of
ABC transporters is frequently associated with disease. This review examines links between …