Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of
plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis …

Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Atherosclerosis is a significant cardiovascular burden and a leading cause of death
worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

Pyroptosis is a form of programmed cell death activated by various stimuli and is
characterized by inflammasome assembly, membrane pore formation, and the secretion of …

Cardiovascular disease (CVD) is a common disease that poses a huge threat to human
health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative …

Programmed cell deaths are pathways involving cells playing an active role in their own
destruction. Depending on the signaling system of the process, programmed cell death can …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …