BACKGROUND Combined androgen blockade (CAB)(medical or surgical castration plus
antiandrogen therapy) is considered by many to be the optimal endocrine maneuver for …

BACKGROUND More than 50,000 male patients received hormonal therapy for metastatic
prostate carcinoma in 1995. Nonsteroidal antiandrogens, such as flutamide, when used in …

PURPOSE: We confirmed the reported rate of prostate specific antigen (PSA) suppression
after flutamide withdrawal in patients with metastatic prostatic carcinoma, increasing serum …

We have conducted a double-blind comparative study of flutamide and chlormadinone
acetate (CMA) on patients with stage C or D prostatic cancer and with no prior experience of …

Flutamide is rapidly metabolized by hydroxylation of the side chain to SCH 16423 (alpha,
alpha, alpha-trifluoro-2-methyl-4′-nitro-m-lactotoluidide), the major metabolic product in all …

Total androgen deprivation is by many clinicians considered to be the optimal therapeutic
regimen for hormone sensitive prostate cancer (1-2). Complete androgen blockade is …

A multicenter, randomized, double-blind study was undertaken to evaluate the efficacy of the
antiandrogen flutamide in treating patients with urinary obstruction caused by benign …

Fifty-two patients with previously untreated metastatic carcinoma of the prostate were treated
with flutamide 250 mg tid. Response was classified according to objective and subjective …

Ten men with prostatic cancer, stage T3M0 Nx or more, who were anxious to maintain
sexual potency, were treated with flutamide. The eight metastasis-free tumours remained …

The effect of flutamide withdrawal was studied in 40 patients with stage D2 prostate cancer
showing progression of the disease after an initial and long (average 3.9 years) period of …