Introduction: High-grade prostatic intraepithelial neoplasia (HGPIN) is generally accepted to
be a precursor lesion of prostate cancer. The likely outcome of isolated low-grade PIN …

Methods The effect of Flu 10, 25, and 50 mg. kg-1 ig on the prostate was tested in
orchiectomized rats with sc testosterone daily for 30 d and in mice implanted with …

We analyzed clinical effects of flutamide as a second‐line agent for maximum androgen
blockade (MAB) in patients with relapsing prostate cancer who received bicalutamide as the …

PURPOSE: A randomized, double-blind, dose finding, placebo controlled, parallel group
clinical study was done to determine the incidence of prostate cancer in men with high grade …

Objectives. Prostatic intraepithelial neoplasia (PIN) is considered the most likely precursor of
prostatic adenocarcinoma. The effect of androgen deprivation therapy on the prevalence of …

High-grade prostatic intraepithelial neoplasia is the most likely precursor of prostatic
adenocarcinoma, according to virtually all available evidence. It has a high predictive value …

High-grade prostatic intraepithelial neoplasia (HGPIN) is commonly encountered on
prostate needle biopsies and, based on epidemiologic, molecular, and animal models, has …

The present study describes a method for the measurement of the plasma levels of hydroxy‐
flutamide (Flu‐OH), the biologically active and main circulating metabolite of flutamide. We …

Objectives: To examine the effects of flutamide and hydroxyflutamide on the transactivation
of mutant androgen receptors. Methods: Androgen‐independent human prostate cancer cell …

The effects of flutamide, an antiandrogen, on prostate tissue concentrations of total DHT,
DHT present in both crude and purified nuclear fractions, prostatic acid phosphatase (PAP) …