Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the
development of autoimmune diseases. However, Treg cells are abundant in tumors and …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

The immune system mediates powerful effector mechanisms to protect against a diversity of
pathogens and equally as important regulatory functions, to limit collateral damage of …

Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune
responses. Treg cells induce tolerance against self‐and foreign antigens, thus preventing …

Tregs have a role in immunological tolerance and immune homeostasis by suppressing
immune reactions, and its therapeutic potential is critical in autoimmune diseases and …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Regulatory T (Treg) cells are found at elevated densities in many human cancers and are
thought to be a major barrier to the generation of robust antitumor T cell responses. In this …

The inflammatory response to transformed cells forms the cornerstone of natural or
therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Over the last years a number of reports have described elevated numbers of regulatory T
(Treg) cells inside of tumors, in close proximity of the tumor, draining lymph nodes and also …