G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gβγ. The
binding sites of Gβγ in the ubiquitous GIRK1 (Kir3. 1) subunit have not been unequivocally …

G protein-activated K+ channels (GIRKs; Kir3) are activated by direct binding of Gβγ
subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin …

We have previously shown that direct binding of the βγ subunit of G protein (Gβγ) to both the
N-terminal domain and the C-terminal domain of a cloned G protein-gated inward-rectifying …

G protein-sensitive inwardly rectifying potassium (GIRK) channels are activated through
direct interactions of their cytoplasmic N-and C-terminal domains with the βγ subunits of G …

In order to find out the functional roles of cytosolic regions of a G protein-activated, inwardly
rectifying potassium channel subunit we studied block of GIRK channels, expressed in …

G protein activated K+ channels (GIRK, Kir3) are switched on by direct binding of Gβγ
following activation of Gi/o proteins via G protein‐coupled receptors (GPCRs). Although Gαi …

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct interaction with Gβγ.
Gα is essential for specific signaling and regulates basal activity of GIRK (I basal) and …

The cardiac G protein-gated K+ channel, I KACh, is directly activated by G protein βγ
subunits (G βγ). I KACh is composed of two inward rectifier K+ channel subunits, GIRK1 and …

GIRK (Kir3) channels are activated by neurotransmitters coupled to G proteins, via a direct
binding of G βγ. The role of Gα subunits in GIRK gating is elusive. Here we demonstrate that …

Gβγ subunits interact directly and activateG protein-gated Inwardly RectifyingK+(GIRK)
channels. Little is known about the identity of functionally important interactions between …