Current hypotheses on the mechanisms of toxicity of ultrafine particles.

K Donaldson, V Stone - Annali dell'Istituto superiore di sanitÃ, 2003 - europepmc.org
PM10 is a complex mixture of particles and we have focused here on the ultrafine
component, ie particles with a diameter of less than 100 nm. In PM10 this fraction is mostly …

The pulmonary toxicology of ultrafine particles

K Donaldson, D Brown, A Clouter, R Duffin… - Journal of aerosol …, 2002 - liebertpub.com
Ultrafine particles are a component of air pollution, derived from primary combustion
sources, and so we have undertaken a programme of study on the mechanisms of lung …

The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types

CAJ Dick, DM Brown, K Donaldson, V Stone - Inhalation toxicology, 2003 - Taylor & Francis
PM 10 contains an ultrafine component, which is generally derived from combustion
processes. This ultrafine fraction may be a factor in the increases in exacerbations of …

Ultrafine (nanometre) particle mediated lung injury

K Donaldson, XY Li, W MacNee - Journal of aerosol science, 1998 - Elsevier
Experimental studies have shown that rats exposed to ultrafine particles of, for example,
titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed …

Ultrafine particles: mechanisms of lung injury

K Donaldson, V Stone, PS Gilmour… - … of the Royal …, 2000 - royalsocietypublishing.org
Many ultrafine particles comprised classically of low–toxicity, low–solubility materials such
as carbon black and titanium dioxide have been found to have greater toxicity than larger …

Toxicology of ultrafine particles: in vivo studies

G Oberdürster - … Transactions of the Royal Society of …, 2000 - royalsocietypublishing.org
Ultrafine particles (less than 100 nm in diameter) are encountered in ambient air and at the
workplace. Normal background levels in the urban atmosphere for ultrafine particles are in …

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines

DM Brown, MR Wilson, W MacNee, V Stone… - Toxicology and applied …, 2001 - Elsevier
Studies into the effects of ultrafine particles in the lung have shown adverse effects
considered to be due in part to the particle size. Air pollution particles (PM10) are associated …

Acute pulmonary effects of ultrafine particles in rats and mice.

G Oberdörster, JN Finkelstein, C Johnston… - … report (Health Effects …, 2000 - europepmc.org
Ambient fine particles consist of ultrafine particles (< 100 nm) and accumulation-mode
particles (approximately 100 to 1,000 nm). Our hypothesis that ultrafine particles can have …

Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types

LC Renwick, D Brown, A Clouter… - Occupational and …, 2004 - oem.bmj.com
Background: Ultrafine particles have been hypothesised to be an important contributing
factor in the toxicity and adverse health effects of particulate air pollution (PM10) and …

Pulmonary effects of inhaled ultrafine particles

G Oberdörster - … archives of occupational and environmental health, 2000 - Springer
Abstract Introduction and Objectives: Recent epidemiological studies have shown an
association between increased particulate urban air pollution and adverse health effects on …