Transcriptional pausing by RNA polymerases (RNAPs) is a key mechanism to regulate gene
expression in all kingdoms of life and is a prerequisite for transcription termination. The …

NusA is a core, multidomain regulator of transcript elongation in bacteria and archaea.
Bacterial NusA interacts with elongating complexes and the nascent RNA transcript in ways …

RNA polymerase (RNAP) frequently pauses during the transcription of DNA to RNA to
regulate gene expression. Transcription factors NusA and NusG modulate pausing, have …

Transcript elongation by bacterial RNA polymerase (RNAP) is thought to be regulated at
pause sites by open versus closed positions of the RNAP clamp domain, pause-suppressing …

NusG is a transcription elongation factor that stimulates transcription pausing in Gram+
bacteria including B. subtilis by sequence-specific interaction with a conserved pause …

In all organisms, RNA polymerase (RNAP) relies on accessory factors to complete synthesis
of long RNAs. These factors increase RNAP processivity by reducing pausing and …

NusA and NusG are major regulators of bacterial transcription elongation, which act either in
concert or antagonistically. Both bind to RNA polymerase (RNAP), regulating pausing as …

Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for
regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for …

Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial
and diverse roles in gene expression. In bacteria, RNA structures are thought to fold within …

Pausing by RNA polymerase (RNAP) during transcription regulates gene expression in all
domains of life. In this review, we recap the history of transcriptional pausing discovery …