Cell division orientation during animal development can serve to correctly organize and
shape tissues, create cellular diversity or both. The underlying cellular mechanism is …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

Orientation of the cell division axis is essential for the correct development and maintenance
of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of …

The direction in which a cell divides is determined by the orientation of its mitotic spindle at
metaphase. Spindle orientation is therefore important for a wide range of developmental …

During development, the establishment of proper tissue architecture depends upon the
coordinated control of cell divisions not only in space and time, but also direction. Execution …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

The ability to dictate cell fate decisions is critical during animal development. Moreover,
faithful execution of this process ensures proper tissue homeostasis throughout adulthood …

The orientation of cell division has a crucial role in early embryo body plan specification,
axis determination and cell fate diversity generation, as well as in the morphogenesis of …

Accurate animal cell division requires precise coordination of changes in the structure of the
microtubule-based spindle and the actin-based cell cortex. Here, we use a series of …

The process of oriented divisions of polarised cells is a recurrent mechanism of cell fate
diversification in development. It is commonly assumed that a specialised mechanism of …