Rationale: In persons with cystic fibrosis (CF), repeated exacerbations of pulmonary
symptoms are associated with a progressive decline in lung function. Changes in the airway …

Cystic fibrosis (CF) is a genetic disease resulting in chronic polymicrobial infections of the
airways and progressive decline in lung function. To gain insight into the underlying causes …

Recent elucidation of the richness and complexity of the microbiome in patients with cystic
fibrosis (CF) has invigorated new discussions of the role of microbial infection in CF beyond …

Rationale: Emerging data support the existence of a microbial “gut-lung” axis that remains
unexplored in bronchiectasis. Methods: Prospective and concurrent sampling of gut (stool) …

The chronic colonization of the lower airways by bacterial pathogens is the leading cause of
morbidity and mortality in patients with cystic fibrosis (CF). Pseudomonas aeruginosa is the …

Until recently, relationships between evidence of colonization or infection by specific
microbial species and the development, persistence or exacerbation of pulmonary disease …

Chronic bacterial lung infections associated with non-cystic fibrosis bronchiectasis represent
a substantial and growing health-care burden. Where Pseudomonas aeruginosa is the …

Chronic pulmonary sepsis is the predominant cause of morbidity for patients with cystic
fibrosis (CF) and non-CF bronchiectasis. Previously it was thought that respiratory infection …

The composition of the lung microbiome contributes to both health and disease, including
obstructive lung disease. Because it has been estimated that over 70% of the bacterial …

Background Recent work indicates that the airways of persons with cystic fibrosis (CF)
typically harbor complex bacterial communities. However, the day-to-day stability of these …