Background Cystic fibrosis (CF) is caused by inherited mutations in the cystic fibrosis
transmembrane conductance regulator gene and results in a lung environment that is highly …

Cystic fibrosis (CF) manifests in the lungs resulting in chronic microbial infection. Most
morbidity and mortality in CF is due to cycles of pulmonary exacerbations—episodes of …

Background Recent studies suggest that lung microbiome dysbiosis, the disease associated
disruption of the lung microbial community, might play a key role in chronic obstructive …

Background Molecular methods based on phylogenetic differences in the 16S rRNA gene
are able to characterise the microbiota of the respiratory tract in health and disease …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

Chronic obstructive pulmonary disease (COPD) is heterogeneous in development,
progression, and phenotypes. Little is known about the lung microbiome, sampled by …

Background Non-cystic fibrosis bronchiectasis is characterised by irreversibly dilated
bronchi usually associated with chronic sputum production, bacterial colonisation of the …

Background Long-term macrolide treatment has proven benefit in inflammatory airways
diseases, but whether it leads to changes in the composition of respiratory microbiota is …

COPD, asthma, and cystic fibrosis (CF) are obstructive lung diseases with distinct
pathophysiologies and clinical phenotypes. In this paper, we highlight recent advances in …

Rationale: Oropharyngeal (OP) swabs and induced sputum (IS) are used for airway bacteria
surveillance in nonexpectorating children with cystic fibrosis (CF). Molecular analyses of …