Bacterial communities in the airways of cystic fibrosis (CF) patients are, as in other
ecological niches, influenced by autogenic and allogenic factors. However, our …

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are
regarded as respiratory commensals. Using a combination of human cohorts, next …

Rationale: Understanding the role of the airway microbiome in chronic obstructive
pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome …

Rationale: The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization
leads to airway inflammation and progressive lung damage. The logical extension of this …

The healthy lung has previously been considered to be a sterile organ because standard
microbiological culture techniques consistently yield negative results. However, culture …

Background Culture-independent analysis of the respiratory secretions of people with cystic
fibrosis (CF) has identified many bacterial species not previously detected using culture in …

Culture of bacteria from bronchial secretions in respiratory patients has low sensitivity and
does not allow for complete assessment of microbial diversity across different bronchial …

Background Systemic inflammation in bronchiectasis is poorly studied in relation to
aetiology and severity. We hypothesized that molecular patterns of inflammation may define …

Chronic polymicrobial infections of the lung are the foremost cause of morbidity and mortality
in cystic fibrosis (CF) patients. The composition of the microbial flora of the airway alters …

Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often
demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based …