Over the last decade, technological advances have revolutionised efforts to understand the
role played by microbes in airways disease. With the application of ever more sophisticated …

Rationale Recent studies have revealed that the lung microbiota of critically ill patients is
altered and predicts clinical outcomes. The incidence of invasive fungal infections, namely …

Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …

Recent studies analysing immunogenetics and immune mechanisms controlling
susceptibility to chronic bacterial infection in bronchiectasis implicate dysregulated immunity …

Bacteria that infect the airways of persons with cystic fibrosis (CF) include a group of well-
described opportunistic pathogens as well as numerous, mainly obligate or facultative …

Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to
irreversible damage. We sought to examine regional variation in the microbial communities …

Rationale: Chronic hypersensitivity pneumonitis (CHP) is a condition that arises after
repeated exposure and sensitization to inhaled antigens. The lung microbiome is …

BACKGROUND: A diverse array of bacterial species is present in the CF airways, in addition
to those recognised as clinically important. Here, we investigated the relative impact of …

Understanding the significance of bacterial species that colonize and persist in cystic fibrosis
(CF) airways requires a detailed examination of bacterial community structure across a …

Progressive obstructive lung disease secondary to chronic airway infection, coupled with
impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF) …