Rationale: The cystic fibrosis (CF) airways are infected with a diverse polymicrobial
community. Objectives: Understanding how changes in the CF microbiome have occurred …

Rationale: Despite growing evidence for the roles of airway remodeling and bacterial
infection in the progression of non–cystic fibrosis bronchiectasis, relationships between …

Cystic fibrosis (CF) is a common fatal genetic disorder with mortality most often resulting
from microbial infections of the lungs. Culture-independent studies of CF-associated …

In the past several years, advances in sequencing platforms and bioinformatics have
transformed our understanding of the relationship between microbial ecology and human …

The importance of infection in the pathogenesis of cystic fibrosis (CF) lung disease has been
long recognized, and the use of antibiotics targeting bacteria identified in cultures of …

Understanding the microbial flora of the cystic fibrosis (CF) respiratory tract is of
considerable importance, as patient morbidity and death are primarily caused by chronic …

Background Compositional differences in the bronchial bacterial microbiota have been
associated with asthma, but it remains unclear whether the findings are attributable to …

Background Chronic obstructive pulmonary disease (COPD) is a prevalent, progressive
respiratory disease, and acute exacerbations of COPD (AECOPD) can accelerate the …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterized by frequent exacerbation phenotypes independent of disease stage …

Background The sputum microbiome has a potential role in disease phenotyping and risk
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …