CD30, a lymphoid activation marker, is shed into the cell environment after endoproteolytic
cleavage of its ectodomain. Soluble (s) CD30 is able to suppress the Th1-type immune …

T cell activation is controlled by the coordination of stimulatory and negative regulatory
signals which are not completely defined. In this study we tested for a possible direct effect of …

Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid
polarization of lipid rafts (LRs). It has been postulated that a major role of costimulation is to …

Interaction of CD40 with CD154 leads to recruitment of both molecules into lipid rafts,
resulting in bi-directional cell activation. The precise mechanism by which CD154 is …

The receptor-like protein tyrosine phosphatase CD45 is essential for TCR signal
transduction. Substrates of CD45 include the protein tyrosine kinases p56 lck and p59 fyn …

Although signal pathways triggered via the CD40 molecule are well characterized, those
induced via CD154 are less known. This study demonstrates that engagement of CD154 in …

CD147 is an activation induced glycoprotein that promotes the secretion and activation of
matrix metalloproteinases (MMPs) and is upregulated during the differentiation of …

By mutagenesis, we demonstrated that the palmitoylation of the membrane-proximal Cys
396 and Cys 399 of CD4, and the association of CD4 with Lck contribute to the enrichment …

CD14 is a 53‐kd glycoprotein that is mainly expressed in myeloid cells and exists in two
forms. The membrane‐bound form represents the receptor for complexes of …

CD40, a member of the TNF receptor family, is expressed on a variety of immune and non‐
immune cells. Its interaction with its ligand, CD154, plays a pivotal role in humoral and cell …